Who Needs Genetic Testing for Cancer?

Who Needs Genetic Testing for Cancer?


Laura Nathan-Garner

24 days ago at 1:44 AM

You may have been diagnosed with cancer, or perhaps one or more of your relatives has. Should you consider genetic testing to find out if there might be a family link (hereditary cancer)? Here’s what you need to know to make an informed decision.

Most cancer cases aren’t related to family history.

“Only about 5 to 10% of cancer cases are related to genetics,” says Karen Lu, M.D., co-medical director of the Clinical Cancer Genetics Program at MD Anderson. “Genetic testing is a powerful tool to identify those individuals who are at especially increased risk for developing certain cancers because of family history.”

You can inherit an abnormal gene from either one of your parents. And, if you inherit a gene linked to cancer, you’re much more likely to develop the disease — and at a younger age. Breast, colorectal, ovarian, prostate, pancreatic, endometrial, and other cancers sometimes run in the family.

Map your family’s cancer history.

You can begin to gauge your risk for an inherited cancer gene by mapping your family’s cancer history.

Speak with relatives to fill in as much information as possible. Pay special attention to the cancer histories of first- and second-degree blood relatives. First-degree relatives include siblings, parents, and children. Second-degree relatives include grandparents, aunts, uncles, nieces, and nephews.

In general, people at risk for an inherited cancer gene have one or more first- or second-degree family members who were diagnosed with:

  • Cancer before age 50
  • The same type of cancer
  • Two or more different cancers
  • A rare cancer, such as male breast cancer or sarcoma
  • A BRCA1 or BRCA2 mutation

Discuss your family history with your doctor.

Does your family history raise some red flags? Use your family history form to talk to your doctor about your cancer risks.

Based on your family history, your doctor may refer you to a genetic counselor, who will review your family medical history, discuss the role of genetics in cancer and perform a hereditary cancer risk assessment. This assessment covers:

  • Your odds of having a genetic mutation (or abnormal gene)
  • An estimate of your cancer risks
  • Personalized genetic testing recommendations
  • Individualized cancer screening and prevention recommendations

Based on your cancer risk assessment, the genetic counselor may recommend genetic testing. This simply involves having blood drawn.

Carefully weigh the pros and cons of testing

One of the benefits of knowing if you have a genetic mutation is that you can work with your doctor to monitor and address your cancer risks. This can help prevent cancer or find it early, when it’s most treatable.

But your decision won’t just affect you. It will also impact your family, since your test results may forecast their cancer risks, too.

Some people worry that their results will make it harder for them to get insurance coverage. But group insurance plans are prohibited by law from using genetic information to discriminate against you.

No matter what you decide, remember: Finding out that you have a gene mutation doesn’t mean you’ll definitely get cancer. And, learning that you don’t have a gene mutation doesn’t guarantee that you won’t get cancer.


Last activity by Mary Foti

Mary Foti

I'm passionate about the importance of genetic testing. I realize it's a highly personal decision, but finding out I had a BRCA2 mutation may have saved many lives in my family. Now that we know, there are things my affected relatives can do to mitigate their risk as much as possible.

David Sadigursky

When cancer care is delayed or inaccessible there is a lower chance of survival, greater problems associated with treatment and higher costs of care. Early diagnosis improves cancer outcomes by providing care at the earliest possible stage, one way to get early detection is from genetic testing.

Julian Moore

Thanks for the information OneVillage!


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